Residual Solvent and Green Chemistry Reporting
Every extract intended for biological testing or regulatory submission should undergo residual solvent testing, typically by gas chromatography with flame ionisation detection, to confirm compliance with the ICH Q3C permitted daily exposure limits appropriate to the solvent class employed.
Contemporary green extraction reporting increasingly documents the Process Mass Intensity (the ratio of total mass input to mass of extract obtained) as a standardised metric of the overall environmental efficiency of an extraction protocol, allowing different methods and laboratories to be compared on a consistent, quantitative sustainability basis.