Green Analytical Chemistry in Pharmaceutical Quality Assurance
Conventional pharmaceutical analytical methods, particularly liquid chromatographic techniques, frequently consume substantial volumes of organic solvents such as acetonitrile and methanol, generating hazardous waste that carries both environmental and occupational safety implications, as well as economic cost associated with procurement and disposal. Green analytical chemistry addresses this concern through a recognised set of guiding principles that collectively advocate for the direct analysis of samples without extensive preparation where feasible, minimisation of sample and reagent quantities, preferential use of automated and miniaturised analytical techniques, replacement of hazardous solvents and reagents with safer alternatives, reduction of energy consumption, and generation of the minimum practicable quantity of analytical waste. This chapter examines the principles and rationale underpinning green analytical chemistry and their application within pharmaceutical quality assurance.
Chapter overview
The guiding principles of green analytical chemistry and their rationale within pharmaceutical quality assurance.
